Prioritizing persons deprived of liberty in global guidelines for tuberculosis preventive treatment

Summary


Summary

  • Persons deprived of liberty (PDLs) are disproportionately impacted by tuberculosis, with high incidence rates and often limited access to diagnostics, treatment, and preventive measures.
  • The World Health Organization (WHO) expanded its recommendations for tuberculosis preventive treatment (TPT) to many high-risk populations, but their guidance does not include PDL, and most low- and middle-income countries do not routinely provide TPT in prisons.
  • Recent studies demonstrate high acceptability and completion rates of short-course TPT regimens in jails and prisons; costs of these regimens have been markedly reduced through international agreements, making this an opportune for further expanding their use.
  • We argue that PDL should be a priority group for TPT in national guidelines and discuss implementation considerations and resource needs for TPT programs in carceral facilities.
  • Scaling access to TPT for PDL is important for reducing disease and transmission in this population; it is also critical to advancing an equitable response to tuberculosis.

 

Reference

Narayan, A., Salindri, A. D., Keshavjee, S., Muyoyeta, M., Velen, K., Rueda, Z. V., Croda, J., Charalambous, S., García-Basteiro, A. L., Shenoi, S. V., Gonçalves, C. C. M., Ferreira da Silva, L., Possuelo, L. G., Aguirre, S., Estigarribia, G., Sequera, G., Grandjean, L., Telisinghe, L., Herce, M. E., Dockhorn, F., … Andrews, J. R. (2023). Prioritizing persons deprived of liberty in global guidelines for tuberculosis preventive treatment. PLoS medicine, 20(10), e1004288. https://doi.org/10.1371/journal.pmed.1004288

Geographies Global

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