Eng, S., Prem, K., Tuot, S., Pall, C., Tep, S., Hoddinott, G., Ichikawa, M., Yi, S., & Teo, A. K. J. (2026). Persistent respiratory, psychological, and quality-of-life impairments two-years post-tuberculosis: evidence from a cohort study in Cambodia. The European respiratory journal, 2600858. Advance online publication. https://doi.org/10.1183/13993003.00858-2026


Summary

Tuberculosis (TB) remains a major global public health challenge. TB programmes have traditionally focused on bacteriological cure and treatment completion as the final milestone of care. However, negative post-TB-related health outcomes have been increasingly documented in several high-TB-burden settings (1,2). Nevertheless, most studies focus on clinical indicators of pulmonary impairment, with comparatively limited attention to broader patient-centred outcomes such as quality of life, mental health, and stigma. Evidence from many high-burden countries, particularly those in Asia, remains scarce.Using cohort data from Cambodia, this study describes the longitudinal trajectory of respiratory and psychosocial health among TB survivors, highlighting the persistent burden of post-TB morbidity beyond treatment completion. We conducted a prospective cohort study of adults newly diagnosed with all forms of TB in Cambodia, recruited through active case finding (ACF) interventions under the Community Mobilization Initiatives to End Tuberculosis (COMMIT) project (3). Baseline data were collected within 1 month of TB diagnosis, and follow-up assessments were conducted at approximately 1 and 2 years post-baseline (i.e., 7-19 months post-treatment completion). Data were collected using a structured questionnaire administered face-to-face by trained data collectors using REDCap (Research Electronic Data Capture).

Geographies
Cambodia

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